tag:blogger.com,1999:blog-2658003869927046449.post434393860039390613..comments2021-09-06T23:41:31.894-04:00Comments on Kneeless Megafauna: Butter Not Like a Statin After All?Greghttp://www.blogger.com/profile/00966592489321207595noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-2658003869927046449.post-20418375033401715582013-04-02T12:11:49.072-04:002013-04-02T12:11:49.072-04:00oh I think no-functional is likely in the sense th...oh I think no-functional is likely in the sense that is does not participate in the reverse cholesterol transport cycle which is not relevant as it also refers to linkage with other lipids. But low non-HDL is not desirable. Might suggest milk thistle 800mg/day to help detox liver. I'm trying same as have similar situation. Stuarthttps://www.blogger.com/profile/07905609129969558707noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-67957037970625680882013-04-02T12:02:11.555-04:002013-04-02T12:02:11.555-04:00since is so hard to get the fine points in those i...since is so hard to get the fine points in those interviews as I have listened to more than a few I will leave you Dr Dayspring's library so you can get a better sense of the research and application.<br />http://www.lipidcenter.com/pdf/<br /><br />Now even a few rare E3/3 are hyper-absorbers and we do not know if it is gut related or genetic. But my observational experience not being a health professional is one ought to check the cartoid artery with an ultrsound called CIMT around $150 a test or even a Calcium Score CAC to be on the safe side. and get a ApoB test.<br />I think doing a leg press @ 2.5x+ body weight and under <15% bodyfat use plastic calipers or get a tanita innerscan scale is also a good objective.Stuarthttps://www.blogger.com/profile/07905609129969558707noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-74081088487714526982013-04-01T22:05:21.038-04:002013-04-01T22:05:21.038-04:00Agreed, though I'm not sure I would call it &q...Agreed, though I'm not sure I would call it "non-functional" -- it seems to play a role in innate immunity. I am e3/e3 by the way.<br /><br />My non-HDL dropped 90 points in the last week. I'm trying something new, and the effect could be temporary. I should have a new post soon.Greghttps://www.blogger.com/profile/00966592489321207595noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-18517033853786488822013-04-01T21:54:34.365-04:002013-04-01T21:54:34.365-04:00well there are other tests that will confirm wheth...well there are other tests that will confirm whether it is athrogenic but trig response is enough to raise the red flags and take measures. By this time plaque growth can start at double digit growth and become difficult to slow and arrest. Unfortunately this is not widely known by many and it can be life shortening.Stuarthttps://www.blogger.com/profile/07905609129969558707noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-70773068647584563782013-04-01T21:45:19.860-04:002013-04-01T21:45:19.860-04:00well Non-HDL is not a good thing, any cardiologist...well Non-HDL is not a good thing, any cardiologist will tell you.. non-functional its called.<br />http://www.sciencedirect.com/science/article/pii/S0021915013001883<br />http://www.sciencedirect.com/science/article/pii/S0021915008002207<br /><br />so you are likely a hyper-absorber of fat and there is a test for that or are an E4 of ApoE-3/4 or 4/4<br /><br />so better to test and avoid sat fat.. try it with mono like EVOOStuarthttps://www.blogger.com/profile/07905609129969558707noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-67231419452902753632012-11-08T05:27:59.433-05:002012-11-08T05:27:59.433-05:00Did you know that with an HDL of 75 or greater, yo...Did you know that with an HDL of 75 or greater, you have what is known as "longevity syndrome" & will probably live well into your 90's without any evidence of Heart disease?<br /><br />With HDL readings of 100 (!!!), I wouldn't worry too much about particle counts OR particle sizes.aelephanthttps://www.blogger.com/profile/15337430274390797972noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-42239774991848075542012-08-31T19:56:59.354-04:002012-08-31T19:56:59.354-04:00Paul, thanks for the comment. Peter's series i...Paul, thanks for the comment. Peter's series is highly informative and even better, very well referenced. As I mentioned in comments above, nonHDL-C is reported to be highly correlated with apoB (i.e. particle count) in the majority of people. The references Peter cites on this point are in agreement with that conclusion. Based this and other measurements, I have no reason to think I am in the discordant minority. I would rather measure apoB, but I work with the best data I can readily obtain.<br /><br />On a population level, I agree that measuring only HDL and nonHDL cholesterol could miss a significant minority of people who might show high risk based on a measurement of apoB. However, for an individual, even one in that minority, it seems quite likely that apoB and nonHDL-C would still generally move in the same direction in response to this sort of intervention. Of course this could be wrong, it is one of the limitations of the tools I have.<br /><br />I used to measure fasting trigs with the CardioChek PA but they are hardly ever detectable, so I stopped. Postprandial triglycerides are a different and much more interesting story (for another day).Greghttps://www.blogger.com/profile/00966592489321207595noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-52867459520972492912012-08-31T13:17:18.126-04:002012-08-31T13:17:18.126-04:00there is a great summary of a series of articles b...there is a great summary of a series of articles by Dr Peter Attia, about cholesterol, posted at mark's Daily Apple.<br /><br />There, he makes a convincing argument that it is the particle count, not the particle size, or the cholesterol concentration, that matters.<br /><br />http://www.marksdailyapple.com/the-straight-dope-on-cholesterol-10-things-you-need-to-know-part-2/#more-30934<br /><br /><br /><br />In the absence of a particle count the next best thing is the ratio of triglycerides and HDL, the lower the number, the better. But you need a home test for triglycerides<br /><br /><br />Paul Nnoreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-66978570295099545162012-07-15T08:43:57.549-04:002012-07-15T08:43:57.549-04:00Thanks. I've heard the Dayspring interview, it...Thanks. I've heard the Dayspring interview, it is very good. By the way, Dayspring does advocate use of nonHDL-C as a proxy when advanced testing is not available (see <a href="http://www.lipidcenter.com/pdf/Postprandial_and_Fasting_Lipids.pdf" rel="nofollow">www.lipidcenter.com/pdf/Postprandial_and_Fasting_Lipids.pdf</a>)Greghttps://www.blogger.com/profile/00966592489321207595noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-57098002159587608842012-07-14T21:41:49.864-04:002012-07-14T21:41:49.864-04:00Lipidologist Dr. Thomas Dayspring is of the opinio...Lipidologist Dr. Thomas Dayspring is of the opinion that particle count is much more predictive of cardiovascular damage than particle size.<br /><br />Jimmy Moore has a very good interview with him on his site. You would probably find it very interesting, and enlightening.<br /><br />I find your n=1 experiment quite interesting. I'm looking forward to seeing how it all turns out. <br /><br />CheersCharlie Curriehttps://www.blogger.com/profile/16770483116956256534noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-3115726177643231822012-07-14T10:28:40.349-04:002012-07-14T10:28:40.349-04:00Thanks for your comment. I'm not aware of a ho...Thanks for your comment. I'm not aware of a home test for apoB particle count. I could probably cobble together the tools needed for ELISA. The spectrophotometer and materials may be costly (e.g. http://www.biocat.com/products/EA7001-1-AS), but it would be cheaper than NMR.<br /><br />In some people, it appears that nonHDL-C can be quite discordant with apoB particle count, but based on my VAP tests, I don't think I fall into that category (I know that VAP does not directly measure apoB particle count either, but it gives useful information about particle size). Since I can't measure apoB, I'm using nonHDL-C as a proxy, and it seems to be a fairly decent one based on studies I've seen.Greghttps://www.blogger.com/profile/00966592489321207595noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-56241608325243202912012-07-14T00:14:09.879-04:002012-07-14T00:14:09.879-04:00Without the ability to measure partical count, you...Without the ability to measure partical count, you are shooting in the dark when it comes to non-HDL cholesterol. Your total cholesterol could possibly not change, but the particle count could go down, meaning each particle is carrying more cholestrol, meaning each particle is larger - which is good.Charlie Curriehttps://www.blogger.com/profile/16770483116956256534noreply@blogger.com