tag:blogger.com,1999:blog-2658003869927046449.post4289932075569528807..comments2021-09-06T23:41:31.894-04:00Comments on Kneeless Megafauna: How I fell down a murine rabbit holeGreghttp://www.blogger.com/profile/00966592489321207595noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-2658003869927046449.post-57024418405744706312013-04-16T14:28:28.323-04:002013-04-16T14:28:28.323-04:00Epic. So much here. Charting the ways in which com...Epic. So much here. Charting the ways in which common models (mathematical or animal) diverge from humans is a useful and neglected project.Benjamin Mako Hillhttp://mako.ccnoreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-14110228960196098222013-04-16T12:06:05.778-04:002013-04-16T12:06:05.778-04:00Hi, thanks for checking in (I was trying to figure...Hi, thanks for checking in (I was trying to figure out the best way to ask you this question but you found me first). I have read a few of Frayn's papers, good stuff but he uses mixed meals if I recall, like all human studies, while all of the mouse studies seem to be pure fat meals or lipid injections.<br /><br />I had not seen your post on the effects of HFLC on NEFA. Looks very interesting. It does look like there is a tiny bit of postprandial suppression. High average levels are concerning (and fasting glucose can also be higher). I wonder what happens after 6 months, or, say, 2 years, when the weight loss and other apparent benefits of low carb seem to disappear as compared to other diets.<br /><br />Full text of the study is here. I will certainly be reading this one.<br /><br />http://m.ajcn.nutrition.org/content/early/2010/01/27/ajcn.2009.27909.full.pdfGreghttps://www.blogger.com/profile/00966592489321207595noreply@blogger.comtag:blogger.com,1999:blog-2658003869927046449.post-29728828916754264022013-04-16T11:01:53.581-04:002013-04-16T11:01:53.581-04:00Hello!
As regards NEFA, I don't know about ro...Hello!<br /><br />As regards NEFA, I don't know about rodents, but free fatty acids are regulated by release from adipose tissue. In humans the normal pp response is suppression of NEFA release and reduced levels. This does not occur on a HFLC diet (at least in hypocaloric state). http://carbsanity.blogspot.com/2011/02/failure-of-lchf-diets-to-suppress-nefa.html<br /><br />Keith Frayn has done a ton on NEFA and postprandial regulation (most if not all in humans). If you search on his name and NEFA on my blog you'll find many discussions on that ... too many, probably, but perhaps you'll get lucky and hit on one that discusses a study like what you're looking for.CarbSanehttps://www.blogger.com/profile/17739915307890592327noreply@blogger.com